FemtoFiber bCARS

Laser system for broadband (bCARS), impulsive (iSRS), and standard Raman Spectroscopy (CARS/SRS)

Broadband coverage < 500 - > 5500 cm^-1 using bCARS
Spectral resolution < 15 cm^-1
Tunable CARS option covering < 1100 - > 3700 cm^-1
Integrated time-delay and frequency modulation options
Simple, turn-key, and compact solution

Measurement speed, highest spectral coverage, and ease-of-use are essential for advanced CARS / SRS microscopy. Based on these requirements TOPTICA has developed the FemtoFiber bCARS system, which is an ideal laser solution for broadband CARS microscopy covering an ultrabroadband spectral range of < 500 - > 5500 cm^-1. For coherent Raman excitation, the laser features an ultrabroadband laser output from 980 - 1400 nm (< 25 fs), which makes wavelength tuning obsolete, simplifies laser design, and increases measurement speed. Additional options for tunable CARS/SRS as well as short pulse options for impulsive SRS (iSRS) make this laser system the ultimate choice for your research. The turn-key and compact all-fiber design makes operation really simple and enable you to focus on your research.

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Specification

Laser output	Output #1	Output #2	Output #3 (Optional)
Wavelength	780 nm (+/- 10 nm)	980 - 1400 nm (broadband)	850 - 1100 nm (tunable)
Power	100 mW*	30 mW*	> 5 mW (@850 - 1000 nm)
Pulse duration	> 3.4 ps (< 100 fs short pulse option available)	< 25 fs**	> 0.8 ps
Spectral bandwidth	< 15 cm^-1	^---	< 30 cm^-1 (@850 - 1000 nm)
Covered wavenumbers	---	< 500 - > 5500 cm^-1 (broadband)	< 1100 - > 3700 cm^-1 (tunable)
Repetition rate	80 MHz (others on request)
Amplitude modulation (optional)	Pulse-picking down to 40, 20, 10 MHz (others upon request)	Pulse-picking down to 40, 20, 10 MHz (others upon request)
Relative timing control (optional)	Integrated delay line to adjust the relative timing between the laser outputs
Polarization	> 95 %, horizontal
Output coupling	Free space
Power consumption	< 80 W
Cooling	Air-cooled
* higher power upon request \| ** typical value for shortest pulse settings

Additional Information

Typical emission spectrum of Output #1 and tunable Output #3 (linear plot)

Spectral coverage for CARS / SRS of the laser system
References

"For us TOPTICAs FemtoFiber CARS system is the perfect laser for standard as well as broadband CARS and SRS applications. The simple all-fiber design makes the system very easy to work with and allows us to really focus on microscopy and to advance our microscopy methods.” Prof. Dario Polli, Politecnico di Milano, Italy"

“The FemtoFiber bCARS laser solution from "TOPTICA is the perfect fit for broadband CARS microscopy and a real working horse in our user facility. Setting-up the laser was extremely simple and since the first day the laser works reliably without requiring maintenance or alignment.” Prof. Julian Moger, University of Exeter, UK

“TOPTICAs CARS solution is really one of our working horses in the lab! The fiber technology is compact, reliable and quiet. I can fully recommend the laser to every researcher working in the field of CARS microscopy.” Dr. Roberta Galli, TU Dresden, Germany
Applications
- Broadband CARS
- Standard CARS
- Multimodal nonlinear imaging
- Label-free microscopy
- Impulsive SRS
Literature
- R. Houhou et. al., Deep learning as phase retrieval tool for CARS spectra, Optics Express (2020)
- T. Sehm et. al., Label-free multiphoton microscopy as a tool to investigate alterations of cerebral aneurysms, Scientific Reports (2020)
- M. Wysokowski et.al., Extreme biomineralization: the case of the hypermineralized ear bone of gray whale (Eschrichtius robustus), Applied Physics (2020)
- S. Penkov et.al., A metabolic switch regulates the transition between growth and diapause in C. elegans, BMC Biology (2020)
- R. Galli et. al., Identification of distinctive features in human intracranial tumors by label‐free nonlinear multimodal microscopy, Journal of Biophotonics (2019)
- O. Uckermann et. al., Label-free Imaging of Tissue Architecture during Axolotl Peripheral Nerve Regeneration in Comparison to Functional Recovery, Scientific Reports (2019)
- P. Imperadore et. al., Nerve regeneration in the cephalopod mollusc Octopus vulgaris: label-free multiphoton microscopy as a tool for investigation, The Royal Society (2018)
- J. Réhault et. al. Broadband stimulated Raman scattering with Fourier-transform detection, Optics Express (2015)
- Ch. H. Camp Jr. et. al., High-speed coherent Raman fingerprint imaging of biological tissue, Nature Photonics (2014)
- Femtofiber bCARS @ in the contrast facility at the unisversity of Exeter